Chinese Journal of Physiology

46 ; H.C. HOU anp R.K.S. LIM

Dog 595 with a reversed-Pavlov-pouch was observed during the months of September and October. On October 25, both vagi were divided just below the diaphragm, and the basal secretion followed after the vagotomy. The animal died suddenly on the tenth day, when an autopsy showed a dilated stomach, a spastic pylorus and some congestion of the lungs.

The influence of the vagotomy on the secretion is evident from table 2 and fig. 4; while the basal secretion increased in range, the response to meals became much diminished (although the animal took its usual meat-meal greedily—to its own undoing!). The marked reduction in the response to meals may be explained by supposing that the vagotomy delayed gastric digestion and thus the liberation of secretagogues from food.

The increase of basal secretion is hardly significant but supports Litthauer’s statement that double vagotomy causes a continuous (increased) though irregular basal secretion.

An interesting counterpart to the last experiment is supplied by the observations on dog 559, which also began with a reversed-Pavlovpouch. After noting the nature of the basal secretion during the month of August, the muscular bridge connecting pouch and main stomach was divided converting the pouch into a Heidenhain one. From table 2 and fig. 5, it will be seen that the basal secretion diminished in range, but the meal response remained unchanged.

TABLE 2. Percentage frequency of acid secretion in reversed-Pavlov-pouch dogs

before and after vagal and enteric neurotomy |

Secretory rates (mg HCl

| Bee per hour) Mean | Mean Dog | Remarks Aieeecas ln nl 7 basal |active | tion 0-1 | 1-5 | 5-10 |/10-20) 20+ | HCl | HCl | a ; | RP-59d Before 18 | 81 53 16 0 0 2.2 16.2

| | After vagotomy 7 14 G4 14 8 0 3.3 d.4 23 9 0 0 1.8 7.7

RP-559 Before 11 68

After conversion q | } 7 to Heidenhain WS ae : D o Y oe ish