Chinese Journal of Physiology

BASAL SECRETION OF THE STOMACH 51

Two animals with Heidenhain-pouches were followed before and after the transplantation of their pouches (see figs. 7 and 8). Dog 626 was provided with a Heidenhain-pouch on October 12, 1926; after 49 days the pouch was transplanted and observations continued for another 89 days. The basa] secretion increased from 0.7 (¢ 0.6) to 2.4 (g 3.8), while the response to meals mounted from 9.7 (@ 5.0) to 17.3 (g 7.4); the basal secretory range also increased after complete denervation, The animal died from pneumonia on February 28, 1927; at autopsy the couplers were found encapsulated by omentum, and surrounded by calcium deposits (see fig. 11); they were in proper alignment, but probably very little flow occurred through the vein as several new vessels, had developed between the omentum and the pouch.

Dog 636 was provided with a Heidenhain-pouch on December 4, 1926 and the pouch transplanted on March 11, 1927. The basal secretion deteriorated from the time the pouch was constructed but taking the mean value, a change from 1.0 (6 1.2) to 0.8 (o 1.6) was observed after complete denervation (see fig. 8). The response to a meal gradually improved from December 1926 to the time of transplantation; immediately after transplantation the response to meals increased remarkably but finally settled down to the level reached in February. The mean values before and after complete denervation was 11.1 (¢5.1) and 15.3 (6 8.0). This animal died of pneumonia on June 24, 1927, 105 days after the transplantation. The anastomosis were found in good condition, although surrounded by omentum and encrusted with calcium depositions. New vessels were present as 1p the other animals, Not unimportant was the finding of 2 rubber tubes 8.5 and 9.5 cm long in the stomach.

Dog 568 was provided with a transplanted pouch at the outset on August 27, 1926. During the first two weeks the pouch was refractory and it was thought that the transplant had not “taken”. By the third week, however, the pouch had recovered and thereafter exhibited a low basal range of secretion with varying response to meat meals. There were two periods of heightened response, viz., October and November 1926 and during the last months of June and July 1927; in fact from the beginning of 1927 until the death of the animal in August, the basal secretion maintained a steady level of about 0.5 mg HCl per hour, while the response to meals increased gradually from practically no response (below 1 mg) in February to 12 mg in July (see fig. 9). These observations show that seasonal variations do not account for